Anti-Aging & Skin
GHK-Cu
Glycyl-L-Histidyl-L-Lysine Copper Complex
Copper-binding tripeptide · best-evidenced cosmetic peptide
- FDA Status
- OTC cosmetic ingredient · Not regulated as drug
- Class
- Tripeptide · naturally occurring · binds copper
- Sequence
- GHK + Cu²⁺ chelate
- Half-life
- Topical · ~hours in skin
Mechanism of action
- Stimulates collagen and elastin synthesis in dermal fibroblasts
- Modulates expression of ~4,000 genes (genomic data)
- Anti-inflammatory and anti-oxidant via copper redox chemistry
- Stem cell mobilization in skin and hair follicle niches
Research areas
- Topical anti-aging skincare (clinical trials show wrinkle reduction)
- Hair growth (5α-reductase modulation)
- Wound healing (diabetic and chronic wounds)
- Pulmonary fibrosis (early animal research)
Evidence and clinical data
Largest body of cosmetic peptide evidence: ~30+ years of research. Multiple RCTs on topical formulations. Less evidence for injectable forms in humans.
Safety profile
Topical form is among the safest cosmetic peptides. Copper accumulation is theoretical concern but not clinically observed at cosmetic concentrations.
Why this peptide is trending in 2026: Driving the "peptide skincare" wave. Marketed by major beauty brands. Used as benchmark in cosmetic peptide formulation.
Educational use only. PeptideAdvance does not sell GHK-Cu, recommend its use, or provide medical advice. The information above is a summary of published research and regulatory status as of April 2026. Some peptides discussed here are not FDA-approved or are restricted under FDA Category 2 — their use outside of authorized clinical research may carry legal and safety implications. Always consult a licensed healthcare professional.